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Utrecht Cohort for Multiple Breast Cancer Intervention Studies and Long-term Evaluation - The UMBRELLA Cohort

U

UMC Utrecht

Status

Enrolling

Conditions

Breast Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT02839863
NL52651.041.15

Details and patient eligibility

About

Due to better treatment options and earlier detection, survival rates of patients with breast cancer continue to increase. As such, (late) treatment toxicity, (long-term) quality of life and the cosmetic outcome are becoming more important. Also, many competing experimental interventions (e.g. treatment, lifestyle interventions) for breast cancer are being developed, all in need to be properly evaluated before being implemented in routine clinical care. Randomized Controlled Trials are the gold standard to do so, but they have shown many challenges, especially when applied in a cancer setting. The 'cohort multiple Randomized Controlled Trial (cmRCT)' design is a promising design for multiple (simultaneous) randomized evaluations of experimental interventions, with potential for increased recruitment, comparability and long-term outcomes as a standard.

By setting up UMBRELLA, as a prospective cohort according to the cmRCT design, the investigators aim to:

  • provide an infrastructure for efficient, fast and pragmatic evaluation and implementation of experimental interventions
  • gain insight into short and long-term treatment response, toxicity, complications, quality of life and survival of patients with breast cancer.

Enrollment

10,000 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age ≥ 18 years
  • Patients with breast cancer who undergo irradiation in the UMC Utrecht
  • Informed consent - at least - for use of routinely collected clinical data and to fill out questionnaires.

Exclusion criteria

  • Inability to understand the Dutch language

Trial contacts and locations

4

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Central trial contact

Helena M Verkooijen, MD, PhD; Danny A Young-Afat, MD

Data sourced from clinicaltrials.gov

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