UVB Light and Sunscreen

Creighton University

Status and phase: Completed; Phase 4

Conditions: Vitamin D Status

Treatments: Other: UVB; Other: Tanning spray

Study type: Interventional

Funder types: Other

Identifiers

NCT00818467

Creighton 7

Details and patient eligibility

About

Patients need vitamin D which is normally produced in the skin in response to ultraviolet light from the sun. Vitamin D is important for calcium absorption and good bone health. Physicians have been using sunscreens to protect patients from skin cancer and the aging effects of sunlight for a least a half a century. Dermatologists have promoted sunscreen use to restrict sunlight exposure especially in white Caucasians. If this behavior is done 100% of the time when outdoors individuals may suffer from vitamin D deficiency. It is impossible to influence persons' behavior to wear sunscreens all the time when outdoors. With the use of sunless tanning agent (DHA), once a week, we can obtain a continuous sunscreen in the top layer of the skin that will not wash off, can't be removed with soap and water, or removed by perspiration. Under these circumstances we can answer the scientific question, will sunscreen use inhibit the production of vitamin D in the skin?

Enrollment: 50 patients

Sex: All

Ages: 19 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• males or females
• ages 19-50 with less than 16 oz milk per day
• less than 10 hours of sun per week
• no Vitamin D supplements
• no anticonvulsants
• no barbiturates
• no steroids
• no meds that increase photosensitivity
• no granulomatous disease
• no liver or kidney disease
• no history of skin cancer
• BMI less than 30
• skin types I & II

Exclusion criteria

• None

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Tanning spray

Experimental group

Description:

To characterize the 25(OH)D response to 4 weeks of thrice weekly 40 mJ of UV-B light in a group of normal subjects with skin types I and II while using multiple applications of 3% DHA for five weeks.

Treatment:

Other: Tanning spray

UVB

Active Comparator group

Description:

To characterize the 25(OH)D response to 4 weeks of thrice weekly 40 mJ of UV-B light in a control group of normal subjects with skin types I and II who are not using 3% DHA applications.

Treatment:

Other: UVB