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Vaccination Perception in Inflammatory Conditions - Flu, Pneumonia and COVID-19 (OPINION)

U

University of Nottingham

Status

Completed

Conditions

Reactive Arthritis
Vasculitis
Psoriatic Arthritis
Inflammatory Bowel Diseases
Inflammatory Disease
Ankylosing Spondylitis
Systemic Lupus Erythematosus
Rheumatoid Arthritis

Treatments

Other: Semi-structured qualitative interview

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

People with inflammatory diseases are often treated with medications that act to suppress the immune-system, increasing the risk of catching infections. Consequently, vaccination with the pneumonia and seasonal flu vaccines is recommended for them. They were also prioritised to receive the COVID-19 vaccines early in the national rollout.

However, the uptake of the pneumonia and seasonal flu vaccines among this group is lower than ideal. There may be many reasons why they do or do not seek to be vaccinated for these infections, such as the belief it may cause their disease to flare up or lack of knowledge of vaccines effectiveness. Anecdotally there was a high uptake of COVID-19 vaccines in adults with inflammatory conditions, however, concerns about vaccine-induced disease flare-ups and reports of complications deterred some from being vaccinated. A better understanding of why people do and do not seek vaccination may result in more targeted messaging for patients to help overcome vaccine hesitancy for these infectious diseases.

This study aims to explore the drivers and barriers to being vaccinated among adults with common inflammatory conditions and on immune-suppressing medication. They will be invited to participate in a single, semi-structured interview. Interviews will be face-to-face, by telephone or video-call, last up to one hour, and digitally audio-recorded. They will explore participants' understanding of pneumonia, seasonal flu and COVID-19 and the risk they pose to their health, their understanding of vaccinations, beliefs of the benefits and risks of vaccinations for these infections, and reasons for seeking or not seeking vaccination.

Findings will inform messaging about being vaccinated for these infections in patient education leaflets, such as those by patient charities regularly provided at speciality clinics. They will also be disseminated to healthcare professionals to help them better understand the drivers and barriers to vaccination.

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age at-least 18 years,
  • Diagnosed with either rheumatoid arthritis, inflammatory bowel disease, psoriatic arthritis, ankylosing spondylitis, systemic lupus erythematosus, vasculitis (small or large vessel), or reactive arthritis, and
  • At-least one prescription of either methotrexate, azathioprine, 5-mercaptopurine, sulfasalazine, mycophenolate mofetil, leflunomide, ciclosporin, tacrolimus, or sirolimus, biologic agents (such as anti-TNF, anti-CD 20 etc).
  • Ability to give informed consent

Exclusion criteria

  • Age < 18 years
  • Dementia: making it impossible to give informed consent and to comply with interview

Trial design

20 participants in 1 patient group

Patients with an inflammatory disease taking immune-suppressing medication
Treatment:
Other: Semi-structured qualitative interview

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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