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The role of disorders of socio-emotional processes in cerebral diseases such as Alzheimer's disease, frontal temporal dementia, Parkinson's disease, Huntington's disease, traumatic brain injury, stroke, focal lesions, has been recognized recently. Social cognition refers to a large group of emotional and cognitive abilities regulating inter-individuals relationships and it includes mainly theory of mind, emotional information processing and empathy. However, assessment of socio-emotional processes is still largely based on experimental tests that are not validated for clinical purpose. In addition their long duration of administration is not adapted to clinical examination. Finally these tests have not been standardized and normalized in French-speaking population.
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Inclusion criteria
Provision of signed and dated informed consent form (ICF)
Male or female, aged 20 to 80 years inclusive at the time of signing ICF
French-speaking
reliable informant
Controls:
derived from the general population and consenting to participate in the study
Patients:
MMS>18
Patients followed for mild or major neurocognitive disorder related to :
Exclusion criteria
Illiteracy
mental retardation
visual or motor deficit preventing reading, drawing or writing (scores on the reading, drawing or sentence writing subtests of the MMSE = 0)
hearing impairment interfering with understanding of instructions,
history of brain disease, including head injury with loss of consciousness lasting > 15 minutes, stroke, coma or loss of consciousness lasting > 15 minutes, followed for sclerosis or other brain disease, brain radiation therapy, epilepsy currently requiring treatment
history of psychiatric illness (schizophrenia or other psychosis) or ongoing psychiatric illness (major depressive disorder or other condition) currently requiring treatment or requiring a stay > 2 days in a psychiatry unit or anxiety requiring more than one medication at the present time
alcoholism (mean alcohol consumption > 3 standard drinks/day or history of alcohol withdrawal)
use of opiates or other illicit drugs during the previous 3 months or causing withdrawal syndrome
ongoing antidepressant or antiepileptic treatment
anxiolytic or hypnotic treatment initiated or increased during the previous month
general anaesthesia during the previous 3 months
history of heart surgery with cardiopulmonary bypass
comorbidities affecting cognition (respiratory, renal, liver, heart failure...)
women of childbearing potential (defined as pre-menopausal, less than 2 years postmenopausal, or not surgically sterile)
persons placed under judicial protection
Patients :
contraindication to MRI
Controls:
deficit on MMSE <27
Primary purpose
Allocation
Interventional model
Masking
44 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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