Validation of a Clinical Screening Grid for Syndromic Schizophrenia (Schizo-CGH-EXM)

H

Hôpital le Vinatier

Status

Enrolling

Conditions

Schizophrenia

Treatments

Genetic: Array comparative genomic hybridization

Study type

Interventional

Funder types

Other

Identifiers

NCT02746510
2015-A01992-47

Details and patient eligibility

About

Background: Nowadays, despite a large number of studies about schizophrenia and genetics, clinical red flags for syndromic forms of schizophrenia remain poorly documented.

Full description

Methods: This study aims to validate a short clinical screening grid for syndromic forms of schizophrenia linked to a pathogenic Copy Variation Number (CNV). The investigators plan to include 150 patients with defined (DSM V) schizophrenia and aged 15 years and more. The clinical grid will be prospectively fulfilled for every patients on the basis of his/her medical history and clinical examination. Array comparative genomic hybridization (CGH-a) will be performed on jugal mucosae sample to detect precisely syndromic forms of schizophrenia linked to the presence of a pathogenic Copy Number Variation (CNV). In subjects with no CNV that may explain the onset of schizophrenia, the investigators would like to complete the investigations with exome trio sequencing. With this type of very clinical approach, the investigators wish to determine which semiological elements should alert the psychiatrists as to the presence of a syndromic form. The objective is to propose at the end of this study a simple and reliable scale, usable in psychiatry consultation, to guide the genetic screening of forms of syndromic schizophrenia.

Enrollment

150 estimated patients

Sex

All

Ages

15+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patient aged 15 years and more with a schizophrenia defined by the DSM V criterion
  • Informed consent signed by the patient or he/she's legal representant

Exclusion criteria

  • Pregnancy
  • Current psychotic decompensation
  • Patient with a known genetic syndrome

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

150 participants in 1 patient group

Array comparative genomic hybridization
Experimental group
Description:
The investigators plan to include 150 patients with defined (DSM V) schizophrenia and aged 15 years and more. The clinical grid will be prospectively fulfilled for every patients on the basis of his/her medical history and clinical examination. Array comparative genomic hybridization (CGH-a) will be performed on jugal mucosae sample to detect precisely syndromic forms of schizophrenia linked to the presence of a pathogenic Copy Number Variation (CNV) or a pathogenic sequence variation (exome trio sequencing).
Treatment:
Genetic: Array comparative genomic hybridization

Trial contacts and locations

1

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Central trial contact

POISSON Alice, PH; Demily Caroline, PH

Data sourced from clinicaltrials.gov

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