Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin (Val-Dia score)

Civil Hospices of Lyon

Status: Active, not recruiting

Conditions: Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder); Autoimmune Encephalitis

Treatments: Other: Clinical score of Granillo and al.

Study type: Observational

Funder types: Other

Identifiers

NCT05953974

69HCL23_0627

Details and patient eligibility

About

The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.

Enrollment: 350 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years old
• Patient with a definite auto-immune encephalitis (Graus and al. 2016)

Exclusion criteria

• Uncomplete data in acute phase
• Patient with several antibodies
• Opposition

Trial design

350 participants in 5 patient groups

NMDAr patients

Description:

Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti NMDAr

Treatment:

Other: Clinical score of Granillo and al.

LGI1 patients

Description:

Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti LGI1

Treatment:

Other: Clinical score of Granillo and al.

CASPR2 patients

Description:

Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti CASPR2

Treatment:

Other: Clinical score of Granillo and al.

GABAb patients

Description:

Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GABAb

Treatment:

Other: Clinical score of Granillo and al.

GAD patients

Description:

Patients \> or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GAD

Treatment:

Other: Clinical score of Granillo and al.