Validation of a Portable Indirect Calorimeter

University of Colorado Denver (CU Denver)

Status: Terminated

Conditions: Human Energy Expenditure

Treatments: Device: Apollo Device

Study type: Observational

Funder types: Other

Identifiers

NCT04469452

20-0317

Details and patient eligibility

About

This study plans to test the accuracy of a new device (the Apollo EE Device) that measures resting energy expenditure (REE) using only oxygen consumed (VO2). Findings from this study will help determine how this new device compares to the gold standard, indirect calorimetry, which measures REE using VO2 and carbon dioxide production (VCO2). Findings may help develop less expensive and more accessible means of measuring energy expenditure.

Full description

The gold standard for measuring resting metabolic rate (RMR) is metabolic carts that measure oxygen consumption (VO2) and carbon dioxide production (VCO2). The energy equivalent of VO2 ranges from ~4.7-5.0 kcals/L, depending on the ratio of carbohydrate, fat, and protein oxidized. However, RMR can be measured based solely on VO2, because VCO2 has a relatively small effect on energy expenditure estimation. A device that measures RMR based on VO2 and eliminates the need for measuring VCO2 could provide a simple and less expensive alternative to metabolic carts and may have important clinical applications. The overarching goal of this proposal is to validate such a metabolic system by comparing its ability to accurately measure RMR against a metabolic cart.

Enrollment: 35 patients

Sex: All

Ages: 19 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males and females
• 19-99 yrs of age

Exclusion criteria

• Pregnancy

Trial design

35 participants in 1 patient group

Healthy Adults (19-99yrs)

Description:

Healthy adults already enrolled in separate studies using indirect calorimetry to measure RMR within our lab will be recruited for this study. Fifty participants (25 male, 25 female) will be heterogeneous in age, body composition, and physical activity based on the inclusion and exclusion of their respective studies. To test reliability, 25 of the 50 participants will repeat RMR measurements within 1 week of initial measurements.

Treatment:

Device: Apollo Device