Validation of a Predictive Rule for the Diagnosis of Viral Meningitis in Adult Emergency Departments (Adult-BMS)

Centre Hospitalier le Mans

Status: Unknown

Conditions: Meningitis

Study type: Observational

Funder types: Other

Identifiers

NCT05062642

CHM-2020/S02/20

Details and patient eligibility

About

Meningitis is the development of an inflammatory reaction in the meningeal space, most often of infectious origin. Many pathogens can cause meningitis, the severity of which varies greatly. Patients presenting with a febrile meningeal syndrome are most often managed in the emergency room, where the challenge for physicians is to quickly differentiate bacterial and viral meningitis.

Viral meningitis is the most common, with enterovirus meningitis having a classically excellent prognosis. Bacterial meningitis is less frequent but more serious.The current public health objective is to save antibiotics.

Investigator hypothesizes that the BMS score can be used to exclude bacterial meningitis in the emergency department in an adult European population of patients with suspected bacterial meningitis.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient admitted to the Adult Emergency Department of CH Le Mans,CHU Angers, CHU Nantes or Beaujon Hospital.
• Over 18 years old
• Having had a lumbar puncture during their stay in the Adult Emergency Department
• Having had a diagnosis of meningitis defined as a pleocytosis ≥ 5leukocytes/mm3 after correction with CSF red blood cells at a standardized ratio of 500/1.

Exclusion criteria

• Antibiotic therapy within 72 hours of inclusion
• Immunosuppression from any cause
• Presence of petechiae or purpura
• History of recent neurosurgery or head trauma
• Other associated bacterial infection
• Inability to collect information for the BMS score calculation or primary endpoint (e.g., transfer to another facility)
• Minor or adult patient under guardianship or protection