Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications

University of California San Francisco (UCSF)

Status

Terminated

Conditions

Cardiac Disease

Treatments

Device: PET-MRI

Study type

Interventional

Funder types

Other

Identifiers

NCT02062008

Combined PET-MRI

Details and patient eligibility

About

The purpose of this study is to understand how simultaneous PET/MR acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.

Full description

To compare regional myocardial uptake of FDG on images obtained on a standard PET camera with the new PET/MR camera, in patients with coronary artery disease.
To compare viability maps obtained with cardiac MR images and FDG-PET for delineation of myocardial infarct core and border zone, in patients with coronary artery disease.
To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with a previous myocardial infarction.
To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR differ from acquisitions obtained independently, with special focus on attenuation correction methods
To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and myocarditis.
To correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of inflammation.
To evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.

Enrollment

2 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for viability imaging.

Exclusion criteria

Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and eGFR less than 45%.