Validation of Proteomic Analyses for Allergic Asthma and Rhinitis (VAPARA)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Asthma, Allergic; Rhinitis, Allergic

Treatments: Biological: Classification as "asthmatic" or "rhinitis only" via proteomic analysis; Biological: Classification as "asthmatic" or "rhinitis only" according to a metacholine test

Study type: Observational

Funder types: Other

Identifiers

NCT01104012

2009-A00399-48 (Other Identifier)

PHRC-I/2009/NM-01

Details and patient eligibility

About

The purpose of this study is to verify and validate the intrinsic diagnostic value in terms of sensitivity and specificity of proteomic profiles determined during a pre-study for discriminating between allergy related asthma and allergy related rhinitis.

Enrollment: 133 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• signed consent
• never-smokers or non-smoking for at least 2 years + < 5 packs per year
• capable of understanding the study
• patient is affiliated with a social security system
• positive skin tests (at least one for Montpellier region pneumoallergens)
• treated with nasal or inhaled corticoids, leucotriene receptor antagonists, anti-IgE, Theophylline, anti-histamines, sodium cromoglycate, beta-blockers, benzodiazépine, oral corticoids: all these treatments must be interrupted for at least 72 hours

Exclusion criteria

• Co-morbidities: none; no co-morbidities are accepted
• dental infections (any) during the 3 months preceding the study
• suspected alcoholism or drug abuse
• chronic viral infection (hepatitis, HIV)
• patient under guardianship

Trial design

133 participants in 1 patient group

All patients

Description:

Allergy patients, asthma and rhinitis

Treatment:

Biological: Classification as "asthmatic" or "rhinitis only" via proteomic analysis

Biological: Classification as "asthmatic" or "rhinitis only" according to a metacholine test