Validation of Receptor Occupancy Simulation

Seoul National University

Status: Completed

Conditions: Medication Satisfaction; Schizophrenia; Dopamine Receptor Occupancy; Prolactin Level

Study type: Observational

Funder types: Other

Identifiers

NCT01660880

A070001 (Other Grant/Funding Number)

C-1205-094-410

Details and patient eligibility

About

• To estimate dopamine receptor occupancy by aripiprazole using computer simulation
• To measure dopamine receptor occupancy by aripiprazole in patients treated with the antipsychotics
• To validate the simulation result by comparing the receptor occupancy from the simulation with that from the patients

Enrollment: 7 patients

Sex: All

Ages: 20 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of schizophrenia
• treated with aripiprazole or risperidone
• no change in dose of antipsychotics for at least 6 weeks
• total PANSS score should be below 80

Exclusion criteria

• Other psychiatric disorders rather than schizophrenia
• history of head trauma
• positive in urine hCG
• on antidepressant, anticholinergics or mood stabilizer

Trial design

7 participants in 1 patient group

aripiprazole

Description:

Patient group who is treated with aripiprazole