Validation of the 1-minute Sit-to-stand Test in Patients With COPD (STAND-UP)

University of Zurich (UZH)

Status: Completed

Conditions: Pulmonary Disease, Chronic Obstructive

Treatments: Other: 1-minute sit-to-stand test

Study type: Interventional

Funder types: Other

Identifiers

NCT02441725

STAND-UP Study

Details and patient eligibility

About

This is a study to provide an in-depth validation of the 1-minute sit-to-stand test as a measure of exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Patients will perform the 1-minute sit-to-stand test and other validated exercise tests and questionnaires.

Full description

Exercise capacity is a strong predictor for mortality, exacerbations and health-related quality of life (HRQL) in patients with chronic obstructive pulmonary disease (COPD). The 1-minute sit-to-stand test (1-min STS test) is a promising exercise capacity test that is simple to conduct and requires few resources.

This study will provide an in-depth validation of the 1-min STS test, specifically evaluating the tests reliability, validity, responsiveness to change and minimal clinically important difference. The study will also assess the predictive properties of the 1-min STS test with regards to detecting exacerbations, as well as identify patterns of physical activity and patient-reported symptoms of exacerbations.

Enrollment: 55 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD diagnosis according to GOLD criteria; post bronchodilator FEV1/FVC<70%
• Male and female patients ≥40 years of age
• Able to do at least 5 repetitions in the 1-min STS test at baseline assessment
• Written informed consent by the participant

Exclusion criteria

• Lower limb joint surgery in the preceding 3 months
• Too unstable medically to perform exercise tests
• Predominant neurological or musculoskeletal limitation to walking
• Cognitive reading impairment and/or difficulties managing the eDiary and step-counter

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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55 participants in 2 patient groups

Pulmonary Rehabilitation Patients

Other group

Description:

Validation of the 1-minute sit-to-stand test; for participants who consent including a extended daily assessment period of physical activity and patient-reported symptoms of exacerbations: Male and female COPD inpatients (≥40 years of age) from two pulmonary rehabilitation clinics (Klinik Barmelweid and Zürcher Höhenklinik Wald)

Treatment:

Other: 1-minute sit-to-stand test

Acute Care Hospital Patients

Other group

Description:

Validation of the 1-minute sit-to-stand test, including daily assessment of physical activity and patient-reported symptoms of exacerbations: Male and female COPD inpatients from two acute care hospitals (≥40 years of age; Stadtspital Waid and Spital Uster)

Treatment:

Other: 1-minute sit-to-stand test