Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura (FOXIGA-2020)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Pediatric ALL; Rheumatoid Purpura

Treatments: Other: Mass Sepctrometry

Study type: Observational

Funder types: Other

Identifiers

NCT04655378

NIMAO/2020-1/TAT-01

Details and patient eligibility

About

In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree). The aim of this study is to validate the method in terms of repeatability, reproducibility, control of pre-analytical conditions and sample conservation, to complete the screening of IgA glycosylation in individuals of the FoxTreg cohort and to refine the glycopeptide signature to predict renal involvement.

Enrollment: 52 patients

Sex: All

Ages: 3 to 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Patient sera from biobank of the FoxTreg study (NCT02317133)

Trial design

52 participants in 3 patient groups

Acute Rheumatoid Purpura

Treatment:

Other: Mass Sepctrometry

Rheumatoid Purpura in Remission

Treatment:

Other: Mass Sepctrometry

Controls

Description:

Without infection, inflammatory or auto-immune pathology

Treatment:

Other: Mass Sepctrometry