Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)

NHS Foundation Trust

Status: Not yet enrolling

Conditions: Cerebral Blood Flow

Treatments: Procedure: CT angiogram

Study type: Observational

Funder types: Other

Identifiers

NCT05775263

PO3027

Details and patient eligibility

About

This study aims to evaluate both Abdominal Normothermic Regional Perfusion (A-NRP) and Thoracoabdominal-NRP (TA-NRP) techniques, proving that brain blood flow is not resumed during NRP. This will be assessed through the use of two modalities: CT angiogram of the brain and continuous Hb02 readings. The study group hypothesise that such assessment methods will provide evidence to indicate that brain blood flow is not present during NRP and promote trust in the use of such novel techniques in routine practice.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• DCD donors in Cambridge University Hospital
• Planned A-NRP
• Consent for study has been obtained
• Those who meet the appropriate criteria for DCD donation following WOLST
• ≥ 18 years of age
• ≤ 75 years of age

Exclusion criteria

• DBD organ donors
• DCD organ donations outside of Cambridge University Hospital
• DCD donors without planned A-NRP
• DCD donors whose family have withheld consent for brain blood flow investigations.
• Patients who do not meet the appropriate criteria for DCD donation following WOLST
• Patients with injuries that will physically prevent use of the necessary assessment methods

Trial design

10 participants in 2 patient groups

A-NRP

Treatment:

Procedure: CT angiogram

TA-NRP

Treatment:

Procedure: CT angiogram