Validity of Mini Fluid Challenge Post Liver Transplantation

Kasr El Aini Hospital

Status: Completed

Conditions: Liver Transplantation

Treatments: Diagnostic Test: mini fluid challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT03396159

N-6-2018

Details and patient eligibility

About

our study aim to assess the validity of using mini fluid challenge to assess the volaemic status of patients after liver transplantation

Full description

After approval of institutional ethical committee and after informed patient consent, patients fulfilling criteria will be involved. Upon ICU admission, patients will be connected to full monitoring and confirming patient hemodynamic stability and no active bleeding through drains. Patients will be in supine position and baseline readings will be recorded. Fluid responsiveness will be assessed with mini fluid challenge by 150 ml of albumin 5% given over 1 minute. After fluid administration stroke volume (SV) assessed by trans thoracic echo (TTE) and other hemodynamic parameters will be recorded. Remaining 350 ml of albumin 5% will be continued over 14 minute to have total volume given 500 ml. after fluid administration SV and other parameters will be recorded. The fluid challenge will be given intravenously via a specific wide pore venous line. Fluid responsiveness will be defined as an increase in the SV by 15% after the infusion of fluid.

TT Echo Examination:

A single LVOT diameter will be measured for each patient as the distance between the inflection points at the base of the aortic valve cusps from the left parasternal long axis view during systole.

Assuming a circular cross section, the LVOT area will be calculated from the LVOT diameter as:

π X (LVOT diameter/ 2)2 = (LVOT diameter)2 X 0.785 Pulse wave Doppler sampling cursor will be placed in the middle of the LVOT immediately proximal to the aortic valve in 5 chamber apical view.

The sonographer manually will trace the velocity-time envelope (VTI). SV values will be calculated by multiplying VTI by cross sectional area.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients post liver transplantation.
• ASA III- IV
• Age > 18 years

Exclusion criteria

• Age less than 18 years.
• Patient with fulminant liver failure.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

mini fluid challenge

Experimental group

Description:

mini fluid will be given and stroke volume will be assessed before and after

Treatment:

Diagnostic Test: mini fluid challenge