Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia

Seoul National University

Status: Unknown

Conditions: Cerebral Aneurysm

Treatments: Drug: Magnesium Sulfate; Drug: 0.9% saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01460563

Mg_orfil

Details and patient eligibility

About

The investigators hypothesized that valproic acid will increase rocuronium requirement and MgSO4 infusion would reduce requirement of muscle relaxant in craniotomy patients preloaded with sodium valproate.

Full description

Magnesium sulfate (MgSO4) is known to reduce requirement of muscle relaxant.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18- 65 years
• American society of anesthesiology physical status 1,2
• scheduled for elective craniotomy for aneurysm clipping or for superficial temporal artery-middle cerebral artery anastomosis

Exclusion criteria

body mass index <18.5 or >24.9 kg m-2; neuromuscular, renal, cardiovascular or hepatic insufficiency; Glasgow coma scale (GCS) <15; allergy to the study drugs; medications influencing NDMRs; breast feeding; pregnancy; and preoperative epilepsy.

Trial design

60 participants in 3 patient groups, including a placebo group

Mg_orfil

Experimental group

Description:

patients preloaded with sodium valproate receives MgSO4 during the craniotomy.

Treatment:

Drug: Magnesium Sulfate

control_orfil

Placebo Comparator group

Description:

patients preloaded with sodium valproate receives 0.9% saline as placebo.

Treatment:

Drug: 0.9% saline

Drug: 0.9% saline

control_no orfil

Placebo Comparator group

Description:

patients not preloaded with sodium valproate receives 0.9% saline as placebo.

Treatment:

Drug: 0.9% saline

Drug: 0.9% saline