Valuation in Depressed Mood, Anhedonia, and Anxiety

Virginia Polytechnic Institute and State University

Status: Enrolling

Conditions: Neurobehavioral Components of Reward and Loss Valuation

Treatments: Behavioral: valuation without instruction; Behavioral: cognitive behavioral therapy; Behavioral: valuation with instruction

Study type: Interventional

Funder types: Other

Identifiers

NCT05384158

RDOC

Details and patient eligibility

About

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Full description

This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Enrollment: 252 estimated patients

Sex: All

Ages: 25 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Exclusion criteria

• history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

252 participants in 3 patient groups

Cognitive behavioral therapy

Active Comparator group

Description:

cognitive behavioral therapy for depression, anxiety, and/or anhedonia

Treatment:

Behavioral: cognitive behavioral therapy

Valuation with instruction

Active Comparator group

Description:

repeat laboratory sessions of a reward/loss learning computer game with specific instructions

Treatment:

Behavioral: valuation with instruction

Valuation without instruction

Active Comparator group

Description:

repeat laboratory sessions of a reward/loss learning computer game without specific instructions

Treatment:

Behavioral: valuation without instruction