Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis (T2 mapping OS)

Assiut University

Status: Not yet enrolling

Conditions: OA Knee; OA; Osteearthritis

Treatments: Device: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT07316257

T2 mapping in osteoarthritis

Details and patient eligibility

About

This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis

Full description

Osteoarthritis (OA) is one of the most common degenerative joint diseases, affecting more than 500 million people worldwide (1), causing joint pain and stiffness, and negatively affecting quality of life . The knee is the most commonly affected joint, followed by the hand and hip (1).

It is important clinically to diagnose osteoarthritis in its early stages to prevent its inevitable progression (2) Routine MR imaging sequences used in the identification of knee osteoarthritis can assess articular cartilage morphology, but despite its accuracy for identifying deep hyaline cartilage defects which are considered irreversible cartilage degeneration with limited treatment options, it lacks sufficient sensitivity for early cartilage changes and low-grade chondral lesions which are the reversible stages for the potential alteration of the osteoarthritis progression(2).

T2 mapping of hyaline cartilage is an imaging technique for the qualitative and quantitative detection of the cartilage providing convincing color mapping and quantitative detection of the cartilage mainly regarding architecture and changes in water content, proteoglycan, and collagen matrix ultra-structure associated with early cartilage degeneration(3).

T2 mapping is a time constant describing the rate at which energy transfer occurs between water protons in a magnetic field (spin-spin interactions), leading to signal dephasing. In normal healthy articular cartilage, water protons are largely bound in place by a well-organized matrix of collagen fibers, allowing for rapid dephasing, and therefore low T2 values are seen(4). However, in osteoarthritic articular cartilage, the collagen fibers become disorganized, and there are more mobile water protons, resulting in high T2 values. (4).

Enrollment: 70 estimated patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with clinical evidence of osteoarthritis

Exclusion criteria

• • contraindications for MRI such as claustrophobia, heart pacemaker and ferromagnetic implants

  • patients in which the misaligned images or distortions due to motion artifacts made the interpretation of the MRI unreliable.
  • Patients with previous knee operation