Value of Cardiac Magnetic Resonance (CMR) Derived Parameters for Diagnosing Left Ventricular Non-compaction Cardiomyopathy

University of Leipzig

Status: Completed

Conditions: Left Ventricular Hypertrophy; Left Ventricular Failure; Left Ventricular Non-compaction Cardiomyopathy

Study type: Observational

Funder types: Other

Identifiers

NCT01481298

LVNC 2011

Details and patient eligibility

About

Left ventricular non-compaction (LVNC) is a rare cardiomyopathy characterized by numerous excessively prominent left ventricular (LV) trabeculation and deep intertrabecular recesses communicating with the ventricular cavity and severely altering myocardial structure. Although most authors assume a developmental arrest in embryogenesis as the underlying pathology, the mechanisms of LVNC are not fully understood yet. Several gene mutations have been identified to be linked with LVNC and an autosomal dominant inheritance pattern is frequent To date the most commonly used imaging tool for diagnosing LVNC is echocardiography applying the criteria established by Jenni and coauthors However, qualitative parameters to differentiate normal compaction of the myocardium in healthy subjects from LVNC or from other cardiomyopathies like dilative cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) may fail due to highly variable LV trabeculation. Therefore, absolute quantification should be performed. Cardiac magnetic resonance (CMR) has been reported as a promising imaging modality to characterize patients with LVNC as it provides both a high spatial resolution and a good contrast between trabeculation and blood pool Jacquier et al. recently described a value of trabeculated LV myocardial mass above 20% of the global mass of the LV to be highly sensitive and specific for LVNC However, in their approach, a substantial degree of the LV cavity was included into calculated trabecular LV mass and led to systemic overestimation of the latter. Furthermore, the role and prognostic value of myocardial scarring as assessed by delayed enhancement (DE) CMR was not evaluated.

The aim of the retrospective study was to establish revised and extended CMR criteria to distinguish LVNC from DCM, HCM and a group of healthy controls and to improve the assessment of trabeculated mass by excluding intertrabecular blood pool.

Enrollment: 57 patients

Sex: All

Ages: 14 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• left ventricular non-compaction cardiomyopathy
• dilatative cardiomyopathy
• hypertrophic cardiomyopathy or healty controls

Exclusion criteria

• contraindications for magnetic resonance imaging like pacemakers or other metallic implants

Trial design

57 participants in 4 patient groups

LVNC

Description:

12 patients with left ventricular non-compaction cardiomyopathy

HCM

Description:

10 patients with hypertrophic cardiomyopathy

DCM

Description:

11 patients with dilatative cardiomyopathy

controls

Description:

24 healthy controls