Value of Prothrombin Fragment F1+2 in the Diagnosis of Pulmonary Embolism in Patients With Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Pulmonary Embolism; Chronic Obstructive Pulmonary Disease

Treatments: Other: CT pulmonary angio, blood tests

Study type: Observational

Funder types: Other

Identifiers

NCT01626521

0033-12-HYMC

Details and patient eligibility

About

To access the clinical usefulness of F1+2 in the diagnosis of PE in patients with AECOPD who require hospitalization. Specifically, to determine whether F1+2 may have an additional value in the subgroup of patients with an abnormal D-dimer,to determine whether it may increase the proportion of patients in whom PE can be safely ruled out and to determine the sensitivity, specificity and NPV of F1+2 at various cut-off values.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD exacerbation
• Able to give informed consent
• Able to perform spirometry

Exclusion criteria

• Known malignancy
• Known hypercoagulable state
• Receiving anticoagulant treatment
• Pregnancy
• Renal failure
• Allergy to iodine

Trial design

20 participants in 1 patient group

COPD Exacerbation

Description:

Patients admitted to hospital with COPD exacerbation

Treatment:

Other: CT pulmonary angio, blood tests