Value of Von Willebrand Factor in Portal Hypertension

Medical University of Vienna

Status: Unknown

Conditions: Portal Hypertension; Liver Cirrhosis

Study type: Observational

Funder types: Other

Identifiers

NCT01358123

vwfcirr

Details and patient eligibility

About

In patients with liver cirrhosis elevated levels of von Willebrand factor antigen (vWF-Ag) are found frequently but the clinical significance is unclear. vWF-Ag plays an important role in primary haemostasis and development of thrombotic vascular obliteration is discussed as a possible mechanism leading to portal hypertension. Invasive measurement of hepatic venous pressure gradient (HVPG) is the current gold standard for the diagnosis of portal hypertension. The investigators hypothesize that vWF-Ag levels in plasma may correlate with portal pressure and predict clinically significant portal hypertension (CSPH, HVPG >=10mmHg) and its complications.

Full description

Patients with alcoholic, viral (chronic hepatitis C), and cryptogenic liver cirrhosis are included. Portal hemodynamics are assessed by HVPG measurement, vWF-Ag levels were measured by ELISA. Results will be compared. 3 and 6 months mortality will be recorded.

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 98 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Liver cirrhosis

Exclusion criteria

• no HVPG measurement