Vancomycin in the Target Site Treatment of Intracranial Infection

Air Force Military Medical University of People's Liberation Army

Status and phase: Unknown; Phase 4

Conditions: Vancomycin

Treatments: Drug: Vancomycin

Study type: Interventional

Funder types: Other

Identifiers

NCT03585426

XJYY-LL-FJ-045

Details and patient eligibility

About

Vancomycin, a novel intravenously administered antibiotic, currently plays a key role in the management of complicated multi-organism infections. However,current LC-MS/MS methods briefly describe parameters and the only reported internal standard was sometimes difficult to obtain. In our study,an updated LC-MS/MS method for the quantitative analysis of vancomycin in human serum was developed.

Enrollment: 2 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

In ICU; ventricle drainage was carried out; renal function is normal, namely creatinine clearance rate is >60ml/min;

Exclusion criteria

women in pregnancy or lactation;in patients with renal insufficiency, the creatinine clearance rate (Clcr) is less than 60ml/min.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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2 participants in 2 patient groups

Vancomycin 1g q12h

Experimental group

Treatment:

Drug: Vancomycin

Vancomycin 1g q8h

Experimental group

Treatment:

Drug: Vancomycin