Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery

Taipei Veterans General Hospital

Status

Enrolling

Conditions

Spondylolisthesis

Spinal Stenosis

Spinal Fusion

Treatments

Drug: without U-VANCO (vancomycin hydrochloride)

Drug: with U-VANCO (vancomycin hydrochloride)

Study type

Interventional

Funder types

Other

Identifiers

NCT03883022

2017-10-008A

Details and patient eligibility

About

Deep surgical site infection (DSSI) is one of the most challenging complications for spinal surgeons and can lead to a poor clinical outcome. This ambispective study was designed to examine the effect of vancomycin powder mixed with autogenous bone graft and bone substitute on preventing deep surgical site infection (DSSI) in degenerative lumbar fusion surgeries as well as any interference with bony fusion.

Enrollment

400 estimated patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients who have instrumented spine fusion surgery due to failed conservative treatment (bed rest, medication, rehabilitation programs) for 3 to 6 months
Patients who are willing to sign the surgical permit after the surgeon explains all surgical procedures along with the surgical risks
Patients who fully understand the surgical procedures as well as the surgical risks and are willing to sign the surgical permit and the inform consent
Patients who agree one more blood withdrawal after operation

Exclusion criteria