Vancomycin Reduction Practices (VRP) in the NICU

Children's Hospital of Philadelphia (CHOP)

Status: Enrolling

Conditions: Vancomycin; Neonatal Sepsis, Late-Onset; Antibiotic Stewardship

Treatments: Behavioral: External Facilitation

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT06772675

GRT-00003877 (Other Grant/Funding Number)

24-021976

Details and patient eligibility

About

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit & feedback, and use of a clinical decision support tool.

Enrollment: 13 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Level III NICU
• Affiliated with Kaiser Permanente Northern California (KPNC) or Children's Hospital of Philadelphia Newborn Care Network (CNBCN)
• Recruited by study team

Exclusion criteria

• Site not recruited for the study

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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13 participants in 2 patient groups

Sites receiving external facilitation

Experimental group

Description:

Sites will receive guidance from an external facilitator to support uptake of the VRP.

Treatment:

Behavioral: External Facilitation

Sites not receiving external facilitation

No Intervention group

Description:

Sites will not receive guidance from an external facilitator.