Vanderbilt-Zambia Innovations in Global Health Technologies (VZNIGHT)

Macha Research Trust, Zambia

Status: Completed

Conditions: Malaria Diagnosis

Treatments: Other: mBEADS

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02700269

5D43TW009348 (U.S. NIH Grant/Contract)

MRT15003.2

Details and patient eligibility

About

Investigators will evaluate approaches using magnetic bead capture, isolation, and surface tension valve transfer of biomarkers to process capillary blood in order to improve the sensitivity of already approved Rapid Diagnostic Tests (RDTs) for detection of human malaria infection. Results will be compared to those obtained using unenhanced capillary blood specimens directly applied to approved malaria RDTs. Participants seeking care for possible malaria in Zambia will be recruited to enroll in the study.

Enrollment: 278 patients

Sex: All

Ages: 6 months to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals giving written informed consent for themselves
• Children under the age of 18 for whom a parent or guardian can give consent
• Individuals seeking care or treatment of suspected or possible malaria
• Individuals being screened as a contact of someone with recent malaria
• Other individuals willing to have their blood tested for malaria

Exclusion criteria

• Anyone over 18 unwilling or unable to provide informed consent
• Anyone under 18 who does not have a parent or guardian to give consent
• Anyone between the age of 12 and 18 who does not give assent