Variability of Daily Iodine Intake: The Effects of Intra- and Inter-individual Variability in Iodine Nutrition Studies (VIOLET)

Federal Institute of Technology (ETH) Zurich

Status: Completed

Conditions: Iodine Deficiency

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03731312

VIOLET (Other Grant/Funding Number)

Details and patient eligibility

About

Iodine status in populations is assessed using urinary iodine concentration (UIC) measured in spot urine samples. The iodine intake is classified as deficient, sufficient, or excessive iodine based on the median UIC (mUIC). However, this approach has limitations, as it does not quantify the prevalence of individuals with habitually deficient or excess iodine intakes. The EAR cut-point method has the potential to quantify prevalence of iodine deficiency and excess. However, little is known about the effects of the inter- and intra-individual variance of UIC.

The aim of the study is to quantify the intra-individual variability in dietary iodine intake. The overall goal is to estimate the prevalence of iodine deficiency and excess in the study population and propose sample size recommendations for future iodine nutrition population studies. The results will provide evidence guiding international recommendations for iodine nutrition studies.

Enrollment: 206 patients

Sex: Female

Ages: 18 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-pregnant
• Non-lactating
• Non-smoking
• Residence in Switzerland ≥12 months
• Generally healthy
• No family history of goiter
• No exposure to iodine containing contrast agents during the last 12 months - Informed consent given

Exclusion criteria

• Participant is not able to understand the study information or procedure, e.g. due to linguistic barriers

Trial design

206 participants in 1 patient group

Study group

Description:

We will collect two repeated spot urine samples, a DBS sample and obtain weight in all 600 study participants. In a randomly selected subsample (n=200) a third repeat spot urine sample and one 24 h urine will additionally be collected.

Treatment:

Other: No intervention