Variables That Are Correlated to Developing Multiple Endocrine Neoplasia (MEN) and Pancreatic Neuroendocrine Tumors (PNET)

M.D. Anderson Cancer Center

Status: Enrolling

Conditions: Pancreatic Neuroendocrine Tumors; Hyperparathyroidism; Multiple Endocrine Neoplasia

Treatments: Other: Genome Sequencing; Other: Data Review

Study type: Observational

Funder types: Other

Identifiers

NCT03053999

PA12-0892

Details and patient eligibility

About

The study aims to identify predictors of disease in patients with hyperparathyroidism (HPTH) who undergo surgery.

Full description

Researchers aim to identify somatic mutations and inherited genetic variants which may help predict the development of PNET in patients with hyperparathyroidism.

Enrollment: 53 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. MEN1 patients who have undergone parathyroidectomy and did not develop PNET.
2. MEN1 patients who have undergone parathyroidectomy and had surgical removal of PNET.

Exclusion criteria

N/A

Trial design

53 participants in 1 patient group

Parathyroidectomy Tissue and Data

Description:

Analyses includes genome sequencing based analysis to identify novel germline variations in blood DNAs and somatic changes in tumor DNAs, which may contribute to the development of pancreatic tumors. Clinical information retrieved from the patients' medical record including: de-identified demographic data (age, gender, race/ethnicity), medical history, family history, disease status, treatment response, survival information, and selected clinical data from medical record (calcium levels, calcitonin levels).

Treatment:

Other: Data Review

Other: Genome Sequencing