Variants of SARS-CoV-2 Causing COVID-19 in Africa (South-Spike)

ANRS, Emerging Infectious Diseases

Status: Unknown

Conditions: COVID-19

Treatments: Diagnostic Test: RT PCR

Study type: Observational

Funder types: Other

Identifiers

NCT05311891

ANRS 0136s

Details and patient eligibility

About

The main objective of this research is to identify and characterize the different molecular variants of SARS-CoV-2, emerging and / or circulating in several countries of Sub-Saharan Africa (Burkina Faso, Côte d'Ivoire, Gabon, Mali, Chad and Republic of Congo) and determine their role in the evolution of the pandemic.

Full description

The main objective of this research is to identify and characterize the different molecular variants of SARS-CoV-2, emerging and / or circulating in several countries of Sub-Saharan Africa (Burkina Faso, Côte d'Ivoire, Gabon, Mali, Chad and Republic of Congo) and determine their role in the evolution of the pandemic.

The research will combine retrospective and prospective approaches to determine the evolutionary dynamics of the virus since the start of the pandemic. It is planned to sequence the entire Spike protein gene for 1550 viruses and make 300 entire genomes. This work will be supplemented by antibody seroneutralization and respiratory transcriptomics tests, in order to estimate the immuno-virological response of the COVID-19 disease associated with the identified SARS-CoV-2 variants.

Enrollment: 12,600 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Major subject (cf. country)
• Presenting for a SARS-COV-2 diagnosis, whether symptomatic or not
• Not objecting to participating in the research

Exclusion criteria

• NA

Trial design

12,600 participants in 2 patient groups

Retrospective

Description:

12000 participants positive for SARS-COV-2

Treatment:

Diagnostic Test: RT PCR

Prospective

Description:

600 participants positive for SARS-COV-2

Treatment:

Diagnostic Test: RT PCR