Variation of Aortic Compliance Related to Exercise Training With or Without Supervised Sessions (ACT)

University Hospital Center of Martinique

Status: Unknown

Conditions: Cardiovascular Disease

Treatments: Procedure: Exercise training with supervised sessions

Study type: Interventional

Funder types: Other

Identifiers

NCT01939080

12/B/01

2012-A00359-34 (Other Identifier)

Details and patient eligibility

About

Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function, improved glycemic, tension and weight control.

Physiologically, the aorta maintains low left ventricular after-load, promotes optimal sub-endocardial coronary blood flow, and transforms pulsatile into laminar blood flow. Increased aortic stiffness may ultimately contribute to left ventricular dysfunction. Regular exercise training is likely to decrease the pulse wave velocity (a measure of the aortic compliance). Some subjects seem more responsive than others, and they may not expect the same benefit of exercise training. To the best of our knowledge, this has not been explained yet.

Enrollment: 308 estimated patients

Sex: All

Ages: 50 to 69 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 50-69 years, with moderate or high cardiovascular risk

Exclusion criteria

• any physical or medical problem liable to limit the patient' ability to perform the cardiopulmonary exercise testing or the exercise training in safe conditions.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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308 participants in 2 patient groups

Medical supervision

Active Comparator group

Description:

Exercise training with supervised sessions Classics training

Treatment:

Procedure: Exercise training with supervised sessions

No medical supervision

Active Comparator group

Description:

Exercise training without supervised sessions Classics training

Treatment:

Procedure: Exercise training with supervised sessions