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Variation of Aortic Compliance Related to Exercise Training With or Without Supervised Sessions (ACT)

U

University Hospital Center of Martinique

Status

Unknown

Conditions

Cardiovascular Disease

Treatments

Procedure: Exercise training with supervised sessions

Study type

Interventional

Funder types

Other

Identifiers

NCT01939080
12/B/01
2012-A00359-34 (Other Identifier)

Details and patient eligibility

About

Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function, improved glycemic, tension and weight control.

Physiologically, the aorta maintains low left ventricular after-load, promotes optimal sub-endocardial coronary blood flow, and transforms pulsatile into laminar blood flow. Increased aortic stiffness may ultimately contribute to left ventricular dysfunction. Regular exercise training is likely to decrease the pulse wave velocity (a measure of the aortic compliance). Some subjects seem more responsive than others, and they may not expect the same benefit of exercise training. To the best of our knowledge, this has not been explained yet.

Enrollment

308 estimated patients

Sex

All

Ages

50 to 69 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients aged 50-69 years, with moderate or high cardiovascular risk

Exclusion criteria

  • any physical or medical problem liable to limit the patient' ability to perform the cardiopulmonary exercise testing or the exercise training in safe conditions.

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

308 participants in 2 patient groups

Medical supervision
Active Comparator group
Description:
Exercise training with supervised sessions Classics training
Treatment:
Procedure: Exercise training with supervised sessions
No medical supervision
Active Comparator group
Description:
Exercise training without supervised sessions Classics training
Treatment:
Procedure: Exercise training with supervised sessions

Trial contacts and locations

2

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Central trial contact

Armelle JEAN-ETIENNE, MD

Data sourced from clinicaltrials.gov

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