Variations of Portal Flow During the Respiratory Cycle in Healthy Volunteers (RESPIFLUX)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: MRI; Respiratory Amplitude; Portal Blood Flow; Echo Planar Imaging

Treatments: Other: peripheral ECG; Other: Standard MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT04782531

PI2020_843_0150

Details and patient eligibility

About

The analysis of portal vein blood flow is important when assessing the severity and progression of liver disease. It is important to understand normal liver regulation in order to appreciate the evaluation of the effect of treatment during the disease progression. The influence of respiration on hepatic hemodynamics is still poorly understood, although some studies have shown a significant impact. The purpose of this project is to quantify the blood flow variations in the portal vein at different positions during the respiratory cycle by using a fast MRI sequence and an Echo Planar (EPI) acquisition.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 18 ans
• Healthy subject without history of hepatic disease

Exclusion criteria

• history of hepatic pathology
• pregnant woman
• claustrophobia
• major obesity
• any contraindication to MRI exam

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)