Various Serving Sizes of Lentils on Blood Glucose and Insulin

University of Guelph

Status: Completed

Conditions: Healthy

Treatments: Other: 1/4 cup- white potato; Other: 1/4 cup- Small red lentil; Other: 1/4 cup- corn; Other: 1/2 cup- white rice; Other: 1/2 cup- small green lentil; Other: 1/2 cup- small red lentil; Other: 1/4 cup- macaroni; Other: 1/2 cup- white potato; Other: 1/4 cup- Small green lentil; Other: 1/4 cup- white rice; Other: 1/2 cup- corn; Other: 1/2 cup- macaroni

Study type: Interventional

Funder types: Other

Identifiers

NCT02940158

16AU001

Details and patient eligibility

About

The purpose of this study is to assess the effects of consuming either 1/2 or 1/4 cup servings of lentils on post-prandial blood glucose and insulin as compared to 4 types of starchy foods (corn, macaroni, white potato, white rice).

Full description

Eligible participants will undergo a total of 6 study visits. During each visit, a fasted blood sample will be taken by fingerprick, and approximately 500 µL of blood will be dripped into a collection tube. The participant will then consume a meal of either: two types of lentils, corn, macaroni, white rice, or white potato. All study days will be randomized. Each meal will be served in either 1/4 or 1/2 cup servings depending on the study block. Six more blood samples will be taken by fingerprick at 15, 30, 45, 60, 90 and 120 minutes after the beginning of the meal.

Enrollment: 48 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Healthy men and women
• Age 18-40 years
• Body mass index (BMI) 20-30 kg/m2

Exclusion Criteria:

• Tobacco use
• Pregnant or breastfeeding
• Fasting blood glucose ≥ 7.0 mmol/L
• Two hour blood glucose ≥ 11.1 mmol/L after consuming 75g glucose drink (Oral Glucose Tolerance Test beverage)
• Any major medical condition including a history of AIDS or hepatitis
• Medical or surgical event requiring hospitalization within 3 months of randomization
• Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications
• Blood pressure >140/90 mm Hg
• Natural health products (NHPs) used for glycemic control
• Probiotic supplements
• Dietary fibre supplements
• Consumption of >4 servings of pulses per week
• Food allergy or non-food life threatening allergy
• Shift workers
• Alcohol consumption >14 drinks/week or >4 drinks/sitting
• Recent or intended significant weight loss or gain (>4 kg in previous 3 months)
• Elite athletes

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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48 participants in 2 patient groups

1/2 cup

Other group

Description:

1/2 cup serving size arm

Treatment:

Other: 1/2 cup- macaroni

Other: 1/2 cup- corn

Other: 1/2 cup- small red lentil

Other: 1/2 cup- white rice

Other: 1/2 cup- small green lentil

Other: 1/2 cup- white potato

1/4 cup

Other group

Description:

1/4 cup serving size arm

Treatment:

Other: 1/4 cup- white rice

Other: 1/4 cup- macaroni

Other: 1/4 cup- Small red lentil

Other: 1/4 cup- white potato

Other: 1/4 cup- corn

Other: 1/4 cup- Small green lentil