Vascular Endothelial Growth Factor Levels at Hysteroscopic Biopsies Which Taken From Recurrent Pregnancy Loss

Bagcilar Training and Research Hospital

Status: Completed

Conditions: Recurrent Pregnancy Loss Without Current Pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT01735331

BEHGynObs-3

Details and patient eligibility

About

The aim of this study is determine vascular endothelial growth factor levels and angiogenesis/vascularity from hysteroscopic endometrial biopsies which taken from patients who has Recurrent Pregnancy Loss.The endometrial vascular endothelial growth factor levels will be measured by immunohistochemical staining methods due to office hysteroscopic endometrial biopsy after the menstruation at follicular phase of menstrual cycle.

Full description

This study is a prospective,observational,single-center study.Ethical approval was obtained from the Institutional Review Board.This study will be completed 30 patients with Habitual Abortus.

Endometrial vascular endothelial growth factor levels will be measured using Flk-1 / Kinase Domain Receptor / Vascular endothelial growth factor receptor-2, Ab-1 (Rabbit PAb), Vascular Endothelial Growth Factor (VEGF) Ab-7 (VG1), Cluster of Differentiation 34 (Endothelial Cell Marker) Ab-1 (QBEnd/10), Vascular endothelial growth factor receptor-1 (N-term) (FLT1) antibody kits. All assays will be performed according to the manufacturer's instructions.

Enrollment: 30 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Recurrent Pregnancy Loss who accept to join the study.

Exclusion criteria

• Patients whose age of <18 and >45
• Patients with have any pregnancy.

Trial design

30 participants in 2 patient groups

VEGF level

Description:

VEGF level in hysteroscopic endometrial biopsy of the patients with recurrent pregnancy loss.

control group

Description:

Patients with Abnormal Uterine Bleeding