Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors

University of Miami

Status: Completed

Conditions: Cancer Survivor; Pediatric Cancer

Treatments: Procedure: Echocardiography; Procedure: Blood specimen

Study type: Interventional

Funder types: Other

Identifiers

NCT02032121

20070584

Details and patient eligibility

About

Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors. The nature of cardiovascular risk and the interaction between treatment affects and cardiovascular risk factors is unknown. We propose to study vascular inflammatory markers as well as measure of blood vessel stiffness (both of which are predictive of early heart disease) in 100 pediatric cancer survivors and 100 control children. Characterization of vascular inflammation and stiffness in long-term survivors will allow for the development of future interventions to decrease inflammation through both pharmacologic and lifestyle modifications.

Enrollment: 6 patients

Sex: All

Ages: 6 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 6-30 years of age
• 2 years from the completion of therapy for cancer
• free of active disease

Exclusion criteria

• <6 or > 30 years of age
• current cancer treatment or inside of 2 years post treatment
• Active disease/infection

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

Intervention procedures

Experimental group

Description:

All the procedures will be completed for every subject

Treatment:

Procedure: Blood specimen

Procedure: Echocardiography