Vascular Health and Exercise Performance of Overweight Children (VHEPOC)

Stanford University

Status: Completed

Conditions: Patient Compliance

Treatments: Other: Diet and Exercise Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01729273

CHRI-23724

Details and patient eligibility

About

The purpose of this study is to assess exercise performance in 20 healthy children 10-19 years of age with a body mass index greater than 85th percentile and to evaluate the effect of dietary and exercise intervention over 12 weeks.

Full description

Our hypothesis is that the vascular health in these children will improve at the end of intervention. The results of this study will help us in our long-term objective of improving vascular health of children with congenital/acquired heart disease, a group particularly at risk for premature atherosclerosis.

Enrollment: 20 patients

Sex: All

Ages: 10 to 19 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 10-19 years old
• Overweight (BMI > 85 percentile)
• Interested in a 12 week ¬home exercise & nutrition program
• Have computer & internet access
• Can come to Lucile Packard Children's Hospital at Stanford for a 3-hour test at the start & end of the study (so only twice!)
• Are able to come to testing after fasting overnight
• Do not smoke
• Do not take any medications

Exclusion criteria

• non-overweight adolescents

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Diet and Exercise Intervention

Experimental group

Description:

Tests will include EndoPAT analysis to assess endothelial function, applanation tonometry to assess arterial stiffness, carotid artery imaging to assess the wall thickness of the carotid arteries, exercise testing to assess the physical exercise capacity of these children and blood work to evaluate the lipid profile and inflammation status (CRP). The Home Exercise Program will be 3 days a week for 12 weeks and participants will connect with the trainer to perform 45-60 minutes of a combination of strength training and aerobic activity via Skype. The Dietary Approaches to Stop Hypertension(DASH) eating pattern will be prescribed to all participants in the treatment group and specific strategies to achieve goals will be discussed weekly by the participant over the phone.

Treatment:

Other: Diet and Exercise Intervention