Vascular Health and Risk Factors in Children With Down Syndrome

Utah System of Higher Education (USHE)

Status: Completed

Conditions: Down Syndrome; Cardiovascular Risk Factor; Atherosclerosis

Treatments: Other: Evaluate vascular disease risk factors in children with Down Syndrome; Other: Determine the associations between cardiovascular disease risk factors and markers of early atherosclerosis in children with Down Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT04735874

00127761

Details and patient eligibility

About

This is a prospective, multicenter, cross-sectional study to evaluate prevalence of vascular risk factors in children with Down Syndrome and to determine the association between vascular disease risk factors and objective markers of early atherosclerosis.

Enrollment: 55 patients

Sex: All

Ages: 10 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All children with Down Syndrome (10.0-18.0 years of age)
• Children with translocations and mosaicism
• Children with and without CHD

Exclusion criteria

• Patients with a history of hypoplastic arch, coarctation or catheter or surgical based aorta interventions
• Patients who are currently treated or have been treated with chemotherapy for cancer or a myeloproliferative disorder within 1 year of the study
• Participants whose parent/legally authorized representative (LAR) perceives the child is not able to cooperate with vascular imaging studies

Trial design

55 participants in 1 patient group

Children ages 10.0 to 18.0

Treatment:

Other: Evaluate vascular disease risk factors in children with Down Syndrome

Other: Determine the associations between cardiovascular disease risk factors and markers of early atherosclerosis in children with Down Syndrome