Vascular Health With Immobilization and Exercise Training

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University of Copenhagen

Status

Completed

Conditions

Immobilization, Tonic
Physical Activity

Treatments

Other: Training with non immobilized leg
Other: Immobilization
Other: Exercise training with both legs

Study type

Interventional

Funder types

Other

Identifiers

NCT03054376
ANG-CV- IMMOB

Details and patient eligibility

About

The study includes healthy young habitually active subjects. All subjects are subjected to two weeks of immobilization of one leg followed by four weeks of training of both legs. The subjects are randomized to either one-leg training of the non-immobilized leg during the two-week immobilization period or to no training of the non-immobilized leg during the immobilization period. Measures include skeletal muscle morphology, markers of angiogenesis and apoptosis, muscle metabolic markers, vascular function, vascular proteins and performance.

Full description

One leg of young healthy subjects will be immoblized for two weeks. Changes in angiogenic proteins and markers of apoptosis in muscle tissue and muscle extracellular fluid will be determined in both legs and in parallel the functional consequences of immobilization will be assessed. Vascular function and vascular proteins will also be determined. In order to understand how the oxidative capacity of the muscle is altered in parallel with changes in capillarization, markers of mitochondria will be measured .Half of the subjects will be randomized to single-leg training during the immobilization period to assess whether simultaneous training reduces the loss of capillaries, muscle function and vascular function in the immobilized leg. After the immobilization period the study participants will train the immobilized leg and the control leg for four weeks by moderate to intense interval cycle training and the same parameteres as during immobilization will be assessed in both legs. The study will also include measurements of circulating compounds and platelets in blood.

Enrollment

12 patients

Sex

All

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy
  • BMI <25
  • Habitually/moderately physically active

Exclusion criteria

  • Known chronic medical disorder
  • Smoking
  • Excessive alcohol intake
  • Known genetic/familial predisposition for thrombosis
  • Hormonal birth control
  • High level strength or endurance training on a regular basis

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

12 participants in 2 patient groups

Immobilization
Active Comparator group
Description:
After baseline studies, the subjects will have one leg immobilized by full length plaster for two weeks. During the two weeks, the other leg will not be trained. After the two weeks the subjects will train both legs for four weeks.
Treatment:
Other: Exercise training with both legs
Other: Immobilization
Training of non-immobilized leg
Active Comparator group
Description:
After baseline studies, the subjects will have one leg immobilized by full length plaster for two weeks. During the two weeks, the other leg will be trained. After the two weeks the subjects will train both legs for four weeks.
Treatment:
Other: Exercise training with both legs
Other: Immobilization
Other: Training with non immobilized leg

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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