Vascular Reparative Mechanism in Diabetes (RAAS)

The University of Alabama at Birmingham

Status: Active, not recruiting

Conditions: Diabetic Retinopathy

Treatments: Other: Diabetic Patients; Other: Healthy Controls

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02119689

R01HL110170 (U.S. NIH Grant/Contract)

1308798827

Details and patient eligibility

About

The purpose of this research study is to study blood stem cells in diabetic patients and normal patients. We would like to better understand if these cells, called endothelial precursor cells (EPCs), are not working as expected in people with diabetes. We would like to see if the function of these cells can predict the development of diabetic retinopathy.

Diabetic retinopathy is an eye disease associated with diabetes in which the cells of the retina are damaged. It can cause blurred vision, vision loss, blindness or possible bleeding in the retina. Even with current treatments, the quality of life for people with diabetic retinopathy is much reduced.

Enrollment: 78 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men or women 18 years or older
• 39 type 1 or type 2 diabetic patients
• 13 with mild retinopathy
• 13 with moderate retinopathy
• 13 with severe, nonproliferative retinopathy
• 39 age and sex matched healthy controls

Exclusion criteria

• Current pregnancy as evidence by a urine pregnancy test as the blood from a pregnant female will influence the results of the laboratory tests

Trial design

78 participants in 2 patient groups

Diabetic Patients

Description:

Mild, Moderate and Severe Retinopathy

Treatment:

Other: Diabetic Patients

Healthy Controls

Description:

Age and sex matched Healthy Controls

Treatment:

Other: Healthy Controls