Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

McMaster University

Status: Completed

Conditions: Weight-Lifting Exercise Program

Treatments: Behavioral: Lower-repetition, heavier-load; Behavioral: Higher-repetition, lighter-load

Study type: Interventional

Funder types: Other

Identifiers

NCT02842593

REB 14-333-1

Details and patient eligibility

About

This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

Enrollment: 60 estimated patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Aged 18-30 years old
• Non-obese (Body mass index less than 30 kg/m2)
• Non-smoker
• Healthy based on questionnaire responses
• Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion criteria

• Allergies to milk proteins (whey or casein)
• Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
• Arthritic conditions
• Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
• A history of neuromuscular problems
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

60 participants in 2 patient groups

Resistance exercise training

Experimental group

Description:

Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.

Treatment:

Behavioral: Lower-repetition, heavier-load

Behavioral: Higher-repetition, lighter-load

Non-exercising control

No Intervention group

Description:

Continue habitual physical activity for 12 weeks.