Vascular Risk Factors in INPH-patients

Umeå University

Status: Completed

Conditions: Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Hydrocephalus, Normal Pressure; Brain Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT01850914

Dnr 2011-52-31M (Other Identifier)

2011-52-31M

Details and patient eligibility

About

Idiopathic normal pressure hydrocephalus (INPH) is a treatable and a common disease of the elderly. The overall objective of this work is to describe cardio- and cerebrovascular risk factors and vascular disease in shunted INPH-patients compared to an age- and sex matched elderly population, as well as the impact of vascular risk factors and vascular co-morbidity on clinical symptoms and outcome of surgery in INPH-patients. The hypothesis is that INPH-patients have a higher level of vascular risk factors and subclinical organ damage than a normal elderly population, and that the higher the level of existing vascular risk factors, the more severe the symptoms of the hydrocephalic disease.

Enrollment: 860 patients

Sex: All

Ages: 60 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• INPH-patients who underwent surgery 2008-2010 and registered in the Swedish National Register of Hydrocephalus
• age <60 and >85
• (only for controls) living in Umeå

Exclusion criteria

• death
• a known mini mental state estimation <23
• inability to communicate (because of severe stroke, aphasia, dementia)
• (only for controls) individuals with INPH who has not yet underwent surgery, or has not been chosen to undergo surgery.

Trial design

860 participants in 2 patient groups

Shunted patients with INPH

Description:

Cases: Patients with normal pressure hydrocephalus who have underwent surgery. Controls: Sex- and age-matched community based controls.

Populationbased elderly.

Description:

A group of populationbased elderly, matched according to age and sex to the patients with INPH. Vascular risk factors studied.