Determine the sensitivity, specificity and accuracy of vascular ultrasound, using direct and indirect ultrasonographic signs, in the obstructive diseases of iliac venous segment, in patients with advanced chronic venous insufficiency (CEAP 3-6), considering the intravascular ultrasound (IVUS) as the gold standard for this diagnosis.
Develop an algorithm for noninvasive ultrasound investigation of obstructive lesions in the iliac segment in patients with advanced chronic venous insufficiency (CEAP 3-6).
Advanced Chronic Venous Insufficiency (CEAP 3-6) submitted to clinical treatment for at least 1 year with no response.
Subject must be > 18 and < 80 years of age
Willing to participate in and able to understand, read and sign the informed consent document before the planned procedure
On duplex ultrasound: patent common femoral vein, and patent deep femoral vein, and/or femoral vein of the study leg
Exclusion criteria
Subject cannot or will not provide written informed consent
Previous venous stent implantation involving the study leg or inferior vena cava
Previous venovenous bypass surgery involving the study leg
Known reaction or sensitivity to iodinated contrast that cannot be managed with premedication
Subjects who are pregnant (women of childbearing potential must have a negative pregnancy test within 7 days prior to enrollment
Acute deep venous thrombosis involving either leg
Known history of chronic total occlusion of the common femoral vein of the study leg.
Known history of thrombophilia (e.g., protein C or S deficiency, anti-thrombin III deficiency, presence of lupus anticoagulant, etc.)
Venous compression caused by tumor encasement
Venous outflow obstruction caused by tumor thrombus
Life expectancy of less than 6 months
Lower Extremity Arterial Insufficiency
Elevated baseline blood creatinine (value greater than the upper limit of the normal range)
Any concurrent disease or condition that, in the opinion of the Investigator, would make the subject unsuitable for participation in the study; examples include but are not limited to the inability to lie supine for the index procedure (e.g., severe congestive heart failure), thrombocytopenia or other hematological disorders associated with an unacceptable risk of bleeding, implanted orthopedic hardware that precludes proper imaging, etc.