Vascularity Impact on the Treatment Outcome in Malignant Pleural Mesothelioma(VITMPM)

Ain Shams University

Status: Completed

Conditions: Malignant Pleural Mesotheliomas

Treatments: Other: marker CD74 and vascular endothelial growth factor VEGF

Study type: Observational

Funder types: Other

Identifiers

NCT02603315

DR-81

Details and patient eligibility

About

The purpose of this study is to To assess the correlation between the predictive factor of vascularity (CD74) in malignant pleural mesothelioma and treatment results (response rate, and overall survival) .

Full description

This is a randomized controlled retrospective study through Examination of paraffin blocks of the patient selected to be included in the study for assessment of the selected vascularity marker of malignant pleural mesothelioma of both types . The CD74 (LN2) antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed paraffin-embedded tissue sections using Immunohistochemistry test methods.

Enrollment: 50 patients

Sex: All

Ages: 39 to 84 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histopathological confirmation of malignant pleural mesothelioma .

• Full clinical data.

• Availability for follow up: Personal communication will be attempted in order to collect missing information.

  3-The files of all patients will be reviewed to analyze the following :

• Operative data if done .

• Pathological review and immunohistochemistry.

• Laboratory investigations: (routine investigations: complete blood picture,liver and renal function test)

• Radiological investigations:( CXR and CT-chest, Abdominal and pelvic U\S and MRI ).

• Treatment protocols applied: Radiotherapy and Chemotherapy.

• Response and survival after treatment .

Exclusion criteria

• cases not receive chemotherapy ,on available of evaluation after treatment