Vasodilation Effect of Inhalational Anesthetics (VEFIHA)

Nanjing Medical University

Status: Completed

Conditions: General Anesthesia

Treatments: Drug: Enflurane; Drug: Isoflurane; Drug: Sevoflurane; Drug: Desflurane; Drug: Halothane

Study type: Interventional

Funder types: Other

Identifiers

NCT00815269

NJFY0812015

NMU-200812-MZ39

Details and patient eligibility

About

Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.

Enrollment: 300 patients

Sex: All

Ages: 19 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Must be undergoing general anesthesia
• Age between 19-45 years

Exclusion criteria

• With hypertension
• Existing organic dysfunction
• Allergic to inhalant anesthetics
• Alcohol addictive or narcotic dependent patients
• A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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300 participants in 5 patient groups

1

Active Comparator group

Description:

Halothane anesthesia: induction and maintenance with different doses

Treatment:

Drug: Halothane

2

Experimental group

Description:

Isoflurane anesthesia: induction and maintenance with different doses

Treatment:

Drug: Isoflurane

3

Experimental group

Description:

Sevoflurane anesthesia: induction and maintenance with different doses

Treatment:

Drug: Sevoflurane

4

Experimental group

Description:

Desflurane anesthesia: induction and maintenance with different doses

Treatment:

Drug: Desflurane

5

Experimental group

Description:

Enflurane anesthesia: induction and maintenance with different doses

Treatment:

Drug: Enflurane