Vasodilator-induced Hypovolemia in Living Liver Donors

Seoul National University

Status: Completed

Conditions: Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC); CVP and SVV During Living Donor Hepatectomy

Treatments: Procedure: vasodilator induced hypovolemia

Study type: Interventional

Funder types: Other

Identifiers

NCT02033967

MLN_SVV_CVP

Details and patient eligibility

About

Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload. The investigators try to evaluate the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced hypovolemia using the SVV calculated from the validation study will be tested (feasibility study).

Full description

This is a 2-phases study.

first phase validation study : Evaluation of the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia

second phase feasibility study

: Comparison of the surgical field grade between validation study group(CVP guided group) and feasibility study group(SVV guided group)

Enrollment: 54 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult (20-60 yr)
• elective living liver donors

Exclusion criteria

• not obtained informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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54 participants in 2 patient groups

CVP

Active Comparator group

Description:

Central venous pressure-guided vasodilator-induced hypovolemia

Treatment:

Procedure: vasodilator induced hypovolemia

SVV

Experimental group

Description:

stroke volume variation-guided vasodilator-induced hypovolemia

Treatment:

Procedure: vasodilator induced hypovolemia