Vasomotor Reactivity In Cerebral Small Vessel Disease And New Approach To Treat Lacunar Stroke (LA BICHAT)

Viatris

Status and phase: Completed; Phase 4

Conditions: Cerebrovascular Accident; Hypercholesterolemia

Treatments: Drug: Atorvastatin

Study type: Interventional

Funder types: Industry

Identifiers

NCT00163150

A2581063

Details and patient eligibility

About

The main purpose of this study is to evaluate the efficacy of atorvastatin treatment during 3 months (80mg/day) on cerebral vasoreactivity (CVR) in lacunar patients.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinically defined lacunar syndrome 3 months before inclusion
• small deep infarct on diffusion MRI (Diffusion Weighted Imaging)
• no atherothrombotic, cardio-embolic, or other rarer cause.

Exclusion criteria

• patients with past coronary event
• contra-indication for assessment of vasomotor reactivity
• patients being on statin therapy at the time of brain infarction
• contra-indication for statin therapy
• patient still under statin therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind