Vasopressin to Prevent Hypotension During Beach Chair Surgery

Chonnam National University

Status: Completed

Conditions: Rotator Cuff Tear Arthropathy

Treatments: Drug: sevoflurane; Drug: Vasopressins; Drug: Placebo; Drug: propofol

Study type: Observational

Funder types: Other

Identifiers

NCT01687894

CNUH-2012-074

Details and patient eligibility

About

Patients undergoing surgery in beach chair position (BCP) are at risk for cerebral ischaemia. The impacts of arginine vasopressin (AVP) on haemodynamics and cerebral oxygenation are evaluated during surgery in BCP.

Full description

Patients undergoing shoulder surgery in BCP under general anaesthesia are randomly allocated to receive i.v. normal saline (control group) or AVP 0.05 or 0.07 U kg-1 (AVP group, n = 15 each) 2 min before moving into BCP. Mean arterial pressure (MAP), heart rate (HR), jugular venous bulb oxygen saturation (SjvO2) and regional cerebral tissue oxygen saturation (SctO2) are measured before (pre-sitting in supine position) and after patients assumed BCP.

Enrollment: 74 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: elective arthroscopic shoulder surgery under general anesthesia in beach chair position

Exclusion Criteria: preexisting cerebrovascular diseases, history of orthostatic hypotension, age less than 18 yr, and the American Society of Anesthesiologists physical status IV or V

Trial design

74 participants in 4 patient groups

Vasopressins & propofol

Description:

Administer vasopressin 0.05 or 0.07 IU/kg before sitting position during propofol anesthesia.

Treatment:

Drug: propofol

Drug: Vasopressins

Placebo & propofol

Description:

Administer saline 10 ml (placebo) 2 min before beach chair position during propofol anesthesia

Treatment:

Drug: Placebo

Drug: propofol

Vasopressins & sevoflurane

Description:

Administer vasopressin 0.05 or 0.07 IU/kg 2 min before beach chair position during sevoflurane anesthesia

Treatment:

Drug: sevoflurane

Drug: Vasopressins

Placebo & sevoflurane

Description:

Placebo (saline 10 ml) for vasopressin is administered 2 min before beach chair position during sevoflurane anesthesia

Treatment:

Drug: Placebo

Drug: sevoflurane