Vasopressor SAT Study

The University of Chicago

Status: Active, not recruiting

Conditions: Delirium; Low Blood Pressure; Critical Illness

Treatments: Other: sedation awakening trial

Study type: Observational

Funder types: Other

Identifiers

NCT03182335

15-1532

Details and patient eligibility

About

To assess the impact of daily awakening from sedation on the amount of vasoactive medication required in the ICU. The hypothesis of this proposal is that the amount of vasoactive drug required to maintain an adequate mean arterial blood pressure will be reduced during a daily awakening from sedation.

Full description

This observational study will compare mean arterial pressure and vasoactive drug dose recorded at two time points:

1. prior to awakening from sedation
2. during the awakening from sedation trial The vasoactive infusion will be titrated to a mean arterial pressure as determined by the medical team prior to study enrollment. Each enrolled patient will have measurements taken only on the first day of enrollment. Enrolled subjects will also have a delirium assessment using the CAM-ICU tool before the awakening from sedation trial and during the awakening from sedation trial.

Enrollment: 800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• requiring Mechanical ventilation through an endotracheal tube with infusion of sedative or analgesic agent for comfort
• requiring vasoactive drug via central venous catheter for the treatment of shock

Exclusion criteria

• patients receiving Dexmedetomidine as sedative

Trial design

800 participants in 1 patient group

Mechanical Ventilation (MV) with vasoactive infusions

Description:

adult ICU patients who are mechanically ventilated with sedative infusion and/or analgesic infusion and also requiring vasoactive drug infusions for the treatment of shock. Patients will be excluded if receiving dexmedetomidine as sedative.

Treatment:

Other: sedation awakening trial