Vasopressor Support, Mean Arterial Pressure and Capillary Refill Time in Critically Ill Patients

Medical University of Silesia

Status: Enrolling

Conditions: Critical Illness

Treatments: Diagnostic Test: Capillary refill time

Study type: Observational

Funder types: Other

Identifiers

NCT05674084

PCN/CBN/0052/KB/242/22

Details and patient eligibility

About

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are:

• How do vasopressor drugs determine CRT value
• How does mean arterial pressure (MAP) determine CRT value
• How often CRT value is normal (< 3 sec) despite hypotensive MAP (<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.

Full description

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are:

• How does norepinephrine dose influence CRT value
• How does epinephrine dose influence CRT value
• How does argipressin dose influence CRT value
• How does dobutamine dose influence CRT value
• How does mean arterial pressure (MAP) determine CRT value
• How often CRT value is normal (< 3 sec) despite hypotensive MAP (<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose.

CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• critical illness requiring vasopressor support
• invasive blood pressure monitoring

Exclusion criteria

• finger distal phalanx not available
• patient in a room of suboptimal ambient temperature

Trial design

150 participants in 1 patient group

Study group

Description:

Critically ill patients undergoing any vasopressor treatment. CRT will be measured over the course of hospitalization. Maximal number of CRT measurements from a single patient is limited to 5.

Treatment:

Diagnostic Test: Capillary refill time