Vasopressor Use Improves Macrocirculation, But What Are Its Effects on Microcirculation?

Gaziosmanpasa Research and Education Hospital

Status: Completed

Conditions: Tissue Ischemia; Hemodynamic Instability; Septic Shock; Sepsis

Treatments: Diagnostic Test: Vascular Occlusion Test

Study type: Interventional

Funder types: Other

Identifiers

NCT07312071

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Details and patient eligibility

About

To manage the treatment in the intensive care unit for patients with septic shock, central venous oxygen saturation (scvO2) is used as a macrocirculatory indicator, with a target value of 70% or higher being recommended. Tissue oxygenation (stO2) measurement can be implemented to assess the microcirculation in these patients, but a specific target value has not been established yet. The investigators believe that guiding the treatment of septic shock patients based on the measurement of microcirculation using stO2 and evaluating its correlation with scvO2 can reduce mortality.

This study aims to investigate the independent impact of high-dose norepinephrine on microvascular reactivity assessed by NIRS-VOT in patients with septic shock, while also examining how these microcirculatory indices relate to the macrocirculatory marker ScvO₂.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Diagnosis of septic shock
• Receiving vasopressor and mechanical ventilation therapy
• Presence of a central venous catheter that allows ScvO₂ sampling
• Ability to obtain tissue oxygenation (stO₂) measurements using a NIRS probe placed on the thenar eminence
• Written informed consent obtained from patient or legal representative

Exclusion criteria

• Local infection, wound, or skin lesion at the planned NIRS probe application site
• Mean arterial pressure (MAP) < 60 mmHg despite vasopressor therapy
• Pregnancy
• Inability to safely perform the vascular occlusion test (as judged by treating clinician)
• Any condition preventing safe blood sampling or reliable stO₂ measurement

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Study group

Other group

Description:

The study will include adult patients aged 18 and above who are receiving vasopressor therapy due to septic shock in the intensive care unit.

Treatment:

Diagnostic Test: Vascular Occlusion Test