VATS IN PATIENTS WITH ADVANCED OVARIAN MALIGNANCIES

Alexandria University

Status: Active, not recruiting

Conditions: Ovarian Cancer

Treatments: Procedure: VIDEO-ASSISTED THORACOSCOPIC SURGERY

Study type: Observational

Funder types: Other

Identifiers

NCT05840029

VATS and ovarian cancer

Details and patient eligibility

About

Ovarian cancer is the seventh most common cancer and the fifth leading cause of death in women worldwide.

About 70% of patients with epithelial ovarian cancer present with advanced disease which will require a combination of cytoreductive surgery and chemotherapy to give them their best chance of long term survival.The presence of macroscopic pleural disease-especially if undetected and unresected after primary debulking surgery-may alter treatment decision-making and markedly affect survival. Video-Assisted Thoracoscopic Surgery (VATS) allows surgeons, through a minimally invasive approach, to not only drain the pleural effusion but also evaluate macroscopic pleural disease and, when possible, resect gross tumor.

Few studies reported that VATS altered the therapeutic management in ovarian cancer patients leading to an upstaging or down-staging when compared to the CT staging. Therefore, this study will prospectively assess the role of VATS in the diagnosis and management of supradiaphragmatic disease as well as evaluate the impact of VATS findings on the decision of surgical management in patients with advanced ovarian cancer FIGO (The International Federation of Gynecology and Obstetrics) stage III/IV.

Enrollment: 68 patients

Sex: Female

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• FIGO stage III/IV ovarian cancer with or without pleural effusion

Exclusion criteria

1. Previously treated ovarian disease.
2. Patient unfit for single lung ventilation.
3. Patients with previous lung surgery.
4. Patients with possible intrapleural adhesions.
5. Patients who had pulmonary resection.

Trial design

68 participants in 2 patient groups

Group A: Patients who will get neoadjuvant chemotherapy based on VATS finding.

Description:

Patients will be considered to receive neoadjuvant chemotherapy if there is residual intrathoracic disease

Treatment:

Procedure: VIDEO-ASSISTED THORACOSCOPIC SURGERY

Group B: Patients who will proceed into debulking surgery based on VATS finding.

Description:

Patients will be considered to be eligible for complete debulking, if VATS showed no intrathoracic tumor or if VATS achieves complete removal of tumor nodules through intraoperative frozen section histopathological examination.

Treatment:

Procedure: VIDEO-ASSISTED THORACOSCOPIC SURGERY