VCMX, PRF and SCTG Treatment in the Gingival Recessions

Bulent Ecevit University

Status and phase: Completed; Phase 3

Conditions: Gingival Recession, Localized

Treatments: Biological: Volume-Stable Collagen Matrix

Study type: Interventional

Funder types: Other

Identifiers

NCT07345520

21.12.2022/12

Details and patient eligibility

About

Comparison of Volume-Stable Collagen Matrix, Platelet-Rich Fibrin, and Subepithelial Connective Tissue Graft in the Treatment of Multiple Adjacent Gingival Recessions: A Parallel-Group, Randomized, Controlled Clinical Trial

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria were as follows:

1. ≥2 mm buccal recessions affecting ≥2 adjacent maxillary teeth;
2. systemically and periodontally healthy;
3. non-smokers;
4. Miller Class I-II (no interproximal attachment or CEJ loss);
5. probing depth (PD) <3 mm;
6. GT ≥1 mm;
7. KGW ≥2 mm;
8. identifiable CEJ;
9. full-mouth plaque index (PI) <20%(O'Leary et al., 1972) and gingival index (GI) score of 0(Löe, 1967) and
10. vital teeth to be treated.

Exclusion criteria included:

1. smokers;
2. caries/restorations/abrasions in the treated area, furcation involvement;
3. contraindications to surgery;
4. pregnancy or lactation;
5. medications compromising healing;
6. surgery in the same region within 2 years;
7. bleeding disorders;
8. requirement for antibiotic prophylaxis; and
9. collagen allergy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Volume Stable Collagen Matrix+Coronally Advanced Flap

Experimental group

Description:

The pre-prepared Volume Stable Collagen Matrix will be moistened with saline solution (SF) and placed beneath a coronally positioned flap at the recipient site during periodontal surgery.

Treatment:

Biological: Volume-Stable Collagen Matrix

Platelet-Rich Fibrin+Coronally Advanced Flap

Active Comparator group

Description:

Autologous platelet-rich fibrin (PRF) will be prepared from the patient's venous blood according to a standardized protocol and placed beneath a coronally advanced flap at the recipient site during periodontal surgery to enhance soft tissue healing and regeneration.

Treatment:

Biological: Volume-Stable Collagen Matrix

Subepithelial Connective Tissue Graft+Coronally Advanced Flap

Active Comparator group

Description:

A subepithelial connective tissue graft harvested from the patient's palate and placed beneath a coronally positioned flap at the recipient site during periodontal surgery.

Treatment:

Biological: Volume-Stable Collagen Matrix